Synthesis of new sulfonamides, identification of structures, the investigation of biological and antioxidant activity

Which has great importance in our lives and in many of the structures of natural products widely available in nature and heterocyclic compounds are used in a variety of fields. Carbohydrates, nucleic acids, peptides, proteins, alkaloids, terpenes and steroids are important organic compounds containing heterocyclic structures. Studies on the synthesis and biological activity of new heterocyclic compounds of the synthesized compound (antibacterial, antimicrobial, antifungal, anticancer, etc.), anti-corrosive effects have great importance in the literature. The tetrazoles those are a heterocyclic compound are used widely particularly in paint industry, photography, agriculture, medicine, pharmacy and chemistry industry. After the middle of 20th century systematic examination the type of tetrazole compounds usage, mostly in ingredient of pharmaceutical, corrosion inhibitors, making explosives and use of photography, increased the interest to these compounds ever after day. Pyridinium salts of the tetrazole which biologically important compounds products exist by opening ring using in treatment of cancer. It is identified to use in named Tasosartan tetrazole derivative drug can be used in treatment of high blood pressure. Both thiodiazole and oxadiazole are heterocyclic compounds. Oxadiazol derived compounds shows effects antibacterial, anticancer, anti-tuberculosis. Sulphonamides are the antibacterial drugs used in human health and veterinary applications. Sulfonamide type produced commercially in a wide spectrum of agents both Gram (+) and Gram (-) shows high activity against bacteria. In the 1970s, trimethoprim, tetroksoprim or pyrimethamine etc dihydrofolate reductase inhibitors and with a combination of sulfamethoxazole and sulphonamides, such as specific infections (urinary tract and respiratory tract, etc.). Animal diseases, treatment and prevention of these diseases began to be used again. Features described above, the scope of this thesis, it was aimed to synthesise containing tetrazole ring new oxadiazole, thiodiazole and the sulfonamide derivative compound. Structures of all synthesized compounds was carried out with MS, elemental analysis, FT-IR, 1H-NMR and 13C-NMR methods to identified. Later, the synthesized compounds antibacterial, antifungal, antioxidant activities was investigated.