Evaluation of the level of irisin in blood in patients aged 18-28 with polycystic ovary syndrome

Objective: Polycystic ovary syndrome (PCOS) is a common heterogenous endocrinopathy characterized by oligo-ovulation or anovulation, androgen excess and multiple small ovarian cysts.(1) Its frequency is %6-10 according to National Institutes of Health (NIH) and %15 according to Rotterdam criteria (2). In our study we diagnosed PCOS according to Rotterdam 2003 criteria (3). Women with PCOS show high levels of insulin resistance and compensatory hyperinsulinemia compared to unaffected women. It has recently been shown that insulin resistance plays a role in the ethiopathogenesis of PCOS and it has also been shown lately that it is related with long term health risks such as obesity, type 2 diabetes mellitus, hypertension, dyslipidemia, and ischemic heart disease, obstructive sleep apnea syndrome, endometrium cancer and mood disorders. İrisin is a newly identified myokine which plays a role in thermogenesis, glucose homeostasis and energy metabolism by turning white adipose tissue to brown adipose tissue. Irisin has been shown to be associated with insulin resistance and metabolic syndrome. Irisin hormone has been promising in the treatment of metabolic diseases because it increases energy expenditure and causes weight loss. The purpose of this study was to determine and compare the serum levels of irisin in PCOS patients and the control groups and thereas to predict their long term health risks such as the increased metabolic syndrome and cardiovasculer risk. Material and Methods: 64 patients with PCOS diagnosed according to Rotterdam 2003 criteria and 60 healthy controls who admitted to Erzincan Binali Yıldırım University Obstetrics and Gynecology out-patient clinics. Age renage of both groups was 18-28 and they had no additional systemic diseases. Pelvic ultrasounds were performed during a gynecological examination. Height, weight, blood pressure were measured. Fasting glukoz, fasting insulin, total cholesterol, LDL, HDL, trigliserid, total testosterone, FSH, LH, estradiol,free testesteron, homosistein, CRP, TSH, prolactin, DHEAS, AMH, ALT, AST, HbA1c and irisin levels were measured. Patients were evaluated for hirsutism according to the Ferriman Gallwey scoring system. HOMA-IR values were calculated. Results: When the patients with PCOS and control group were compared in terms of clinical features, there was no statistically significant difference between the two groups in terms of age, height, HDL, TG, fasting insulin, FSH, LH, estradiol, TSH, prolactin, AMH, ALT, AST, HOMA-IR index. There was statistically significant difference between two groups in term of weight,body mass index, blood pressure, LDL, total cholesterol, total testesteron, free testesteron, homosistein, CRP, fasting glucose, DHEAS, HbA1c (p<0,05). The irisin levels in the PCOS group were statistically significantly lower than the control group. Conclusions: In our research the irisin levels in the PCOS group were statistically significantly lower than the control group. Key Words: Polycystic over syndrome, irisin level BMI, fasting glucose, fasting insulin