Synthesis of 6-phenyl(4-methylphenyl)-3(2H)-pyridazinon-2-propionamide derivatives and investigation of antimicrobial activity

In present study a series of 6-phenyl/(4-methylphenyl)-3(2H)-pyridazinon-2-propionamide were synthesized. The structures of these new pyridazinone derivatives were confirmed by their IR, 1H-NMR spectra and elementary analysis. Antimicrobial activities of the synthesized compounds were investigated against Escherichia coli (ATCC 25922/isolated strain), Pseudomonas aeroginosa (ATCC 10145/ isolated strain), Proteus mirabilis (ATCC 7002/ isolated strain), Klepsiella pneumoniae (RSKK 574/ isolated strain), Acinetobacer baumannii (RSKK 02026/ isolated strain), Staphylococcus aureus (ATCC 25923/ isolated strain), Enterococcus faecalis (ATCC 29212/ isolated strain) ve Bacillus subtilis (ATCC 6633/ isolated strain), Candida albicans (ATCC 10231) and Candida krusei (ATCC 6258).All of the synthesized compounds exhibited significant activity against Pseudomons aeruginosa(Gram negative bacteria), Acinobacter baumannii(Gram negative bacteria) and Staphylococcus aureus (Gram positive bacteria). The rest of the IVa and IVb derivatives showed weak activity towards Gram positive and Gram negative bacteria when compared to reference compounds. However, one that can say, 6-phenyl -3(2H)-pyridazinon-2-yl-propanamid IVa derivatives have been shown better antibacterial activity than 6-methylphenyl-3(2H)-pyridazinon-2-yl-propanamid IVb derivatives.