The diagnostic value of elabela and Asprosin in patients with acute coronary syndrome in the emergency department

THE DIAGNOSTIC VALUE OF ELABELA AND ASPROSIN IN PATIENTS WITH ACUTE CORONARY SYNDROME IN THE EMERGENCY DEPARTMENT The purpose of this study is to determine the diagnostic value of elabela and asprosin in patients with acute coronary syndrome (ACS). The study includes 112 ACS (STEMI, NSTEMI and UA) patients that presented to the emergency department with chest pain and were hospitalized in the cardiology clinic of Fırat University Hospital. The control group consisted of 58 healthy volunteers. Among the 112 ACS patients, 93 presented to the hospital with myocardial infarction (MI) (55 STEMI and 38 NSTEMI) and 19 with unstable angina (UA). There was a significant difference between the levels of asprosin in experimental and control groups. ROC analysis revealed the cut-off value of elabela to be ≤1110.303 (sensitivity, 79%; specificity, 28%; AUC = 0.502, 95% confidence interval = 0.42-0.57; p = 0.9659). The diagnostic threshold of asprosin was ≤67.298 (sensitivity, 82%; specificity, 37%; AUC = 0.610; 95% confidence interval = 0.53-0.68, p = 0.0191) We conclude that asprosin has a higher diagnostic value than elabela. We recommend further studies to be able to utilize asprosin levels for the differential and early diagnosis of patients that present to the emergency department with chest pain. Keywords: Emergency department, chest pain, elabela, asprosin