The diagnostic value of procalcitonin, c-reactive protein and interleukin-6 in early recognition of severe sepsis

The Diagnostic Value of Procalcitonin, C-Reactive Protein and Interleukin-6 in Early Recognition of Severe Sepsis Objective: In this study, conducted in patients with bacterial infection, Systemic Inflammatory Response Syndrome (SIRS), sepsis, severe sepsis and septic shock, we aimed to assess the diagnostic value of Procalcitonin, C-Reactive Protein and Interleukin-6 levels in early diagnosis. Material and Method: In this study, 100 patients were included. According to clinical diagnosis; 26 children had sepsis (Group I), 17 children had severe sepsis (Group II), 22 children had septic shock (Group III), 9 children had SIRS (Group IV) and 14 children had bacterial infection (Group V) and 12 children were included as control group (Group VI). We recorded patients' age, gender, complaints on admission, physical examination findings, complete blood count values, pulmonary X-ray findings, culture findings, treatment modalities and conditions at the end of treatment. Plasma levels of PCT, CRP and IL-6 were obtained from patients and studied. Results: Mean PCT levels were higher in all patient groups than control group. Statistically there was no significance regarding mean CRP levels between all groups. Mean IL-6 levels were higher in all patient groups than control group. Conclusion: Studies have shown biomarkers like procalcitonin, interleukin-6 and C-reactive protein can be used in early recognition and treatment monitorization of severe sepsis. In our study, we concluded that PCT is a lot more powerful diagnostic biomarker in early diagnosis of sepsis than CRP and IL-6. Key words: SIRS, Sepsis, Severe sepsis, Septic shock, Procalcitonin, C-Reaktif Protein and IL-6.