The relationship between NON-ST segment elevation myocardial infarction and hemogram parameters and monocyte / HDL ratio in angiographyically total occluded coronary artery

Introduction: %25-39 total occlusion has been detected on the coroner angiography at NSTEMI patients according to metaanalyses. NSTEMI patients with total occlusion has been shown that its associated more heart failure, major cardiac undesirable event and death according to recent metaanalyses. Monocytes has a prominent role in inflamation because it is a precursor of macrophages. HDL is an antiaterogenik lypoprotein. Moreover HDL has antioxidan, antitrombotic and antiinflammatory effects. Monocyte/HDL rate is a relatively new marker and studies showing that it is associated with cardiovascular diseases has recently been published. In our study, we investigated the relationship between the ratio of monocyte/HDL and some biomechanical parameters in NSTEMI patients with total occlusion. Method: Coronary angiography of NSTEMI patients at a time period between january 2014 and december 2015 at Bülent Ecevit University has been included to our cross-sectional and retrospective study. 135 patients with all inclusion criteria were included in the study. The age and gender of patients and the presence of hypertension diabetes and hyperlipidemia were recorded in study patients. Blood glucose, urea, creatinin, uric asid, total cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL) and triglyceride (TG) values were taken as biochemical parameters. White blood cell (WBC), hemoglobin, platelet, plateletcrit, red blood cell distribution width (RDW), mean platelet volume (MPV), lymphocyte, monocyte, neutrophil, platelet/lymphocyte ratio, monocyte/high density lipoprotein ratio were recorded as hemogram parameters. We compared these study parameters between two groups. Results: 102 of the patients included in the study were non occluded NSTEMI group and 33 of them were in occluded NSTEMI group. The average age of patients were 60,7±12. Age, gender, hypertension, diyabetes and hyperlipidemia were similar in two groups. There was no statistically significant difference between two groups in terms of biochemical parameters and hemogram parameters except PCT and HDL. There was no significant difference between the two groups in terms of MHR (p = 0.289). PCT was 0.239% (0.112-0.531) in the occluded NSTEMI group and 0.213% (0.093 - 0.637) in the non-occluded NSTEMI group (p = 0.032). HDL was 45 (28-101) mg / dl in the occluded NSTEMI group and 40 (18-72) mg/dl in the non-occluded NSTEMI group (p=0.031). Conclusion: In our study, occluded coronary artery was detected in approximately one fourth of the study patients. We did not find a statistically significant relationship between occlusion and MHR in NSTEMI patients. HDL and PCT levels were significantly higher in the occluded NSTEMI group than the non-occluded NSTEMI group. In order to generalize the results of our study, it should be supported with larger scale and prospective studies.