Synthesis of new tandospirone analogues and isoindoles with antidepressant potential effect

Nowadays, most of the chemical researches are focused on the synthesizing of the new compounds possibly having biological activities, besides determining and measuring of these activities. It has been shown that imides and its derivatives like isoindolines which are active precursors of the important compounds in the pharmacological and medicinal researches have antidepressant, anticancer, antimalarial, antibacterial and fungicidal properties. Furthermore, the arylation and alkenization of alkenes in presence of palladium catalyst in organic synthesis named as Heck reaction, keep their currency as very effective catalyzing method in forming carbon-carbon bonds. Recently, the asymmetric Heck-type hydroarylation of specific bicyclic ring systems of alkenes have been examined intensively, because of the easily obtained stereoselective results. This study planned as three steps. The first step is the synthesizing of starting materials N-[4-((3-trifluoromethylphenyl)piperazin-1-yl)butyl]-10-bicyclo[2.2.1]hept-8-ene-3-endo,5-endo-dicarboximide and its reducing by LiAlH4 obtained 2,3,3a,4,7,7a-Hekzahydro-2-[4-((3-trifluoromethylphenyl)piperazin-1-yl)butyl]-4,7-methano-1H-isoindole. The second step is including hydroarylation reactions of these compounds with aryl iodides. On the third step is including structure characterizations of all new compounds by FTIR, 1H NMR, 13C NMR (APT), LC-MS and GC-MS techniques, respectively.