Antidiyabetik tabletlerin üç boyutlu basımı

This study was conducted to employ the novel technology of three-dimensional printing as an alternative to conventional tableting technology in order to produce geometrically customizable tablet that offers personalized and tunable release profile. In addition to customization of release profile, geometrical design was utilized to enhance the dissolution of poorly water-soluble drug repaglinide from tablet dosage form. Semi-solid extrusion with a three-dimentional (3D) bioprinting machine (EnvisionTEC Bioplotter, Germany) was used as the production technology. Paste of traditional pharmaceutical excipients was formed by mixing powdered component and adding liquid binder. Lactose was used as a filler, PEG 6000 as a plasticizer, while different viscosity grades of hydroxypropylmethyl cellulose (HPMC,100K, and 15K mPa.s) served as release modifier polymers. Repaglinide was the antidiabetic active pharmaceutical ingredient (API) and the model for poorly water-soluble BCS class II drug. The liquid binder was formed as 0.5 % (w/v) gel of HPMC E4M in water, and added in a sufficient amount to create an extrudable, printable paste through a 0.41 mm nozzle. The tablets digital cylindrical design was created using Prefactory® RP program (EnvisionTEC, Germany), and then it was exported to the printer operating program VisualMachines. Two separate formulations were developed using HPMC 100K mPa.s and HPMC 15K mPa.s and, within each formulation, three different types of tablets were printed with strands distances (SD) parameter of 1.0, 1.3, and 1.6 mm (which determined the perforation levels within tablets). The resulting tablets were evaluated by their thickness, diameter, hardness, weight variation, friability, and dissolution profiles. The difference in these attributes were investigated in relation to their HPMC grades and 3D printing SD parameter. Overall, higher perforation levels in tablets and lower viscosity grades of HPMC produced higher rates of dissolution. Additionally, controlling perforations was also successful in enhancing the dissolution of the poorly water-soluble drug repaglinide. Hence, 3DP can be used to design tablets with customized release profiles to suit personalized medication with a 3D printer in clinical settings such as pharmacies and hospitals.