Bakır aljinat yarı-kriyojel kürelerin sentezi ve karakterizasyonu

Alginate biopolymer has several applications-especially in biological fields such as drug release, tissue engineering, and wound dressing, due to its biodegradable, biocompatible, and non-toxic properties. Copper ion has been used in previous wound dressing studies for its antimicrobial property. In this thesis study, firstly, copper crosslinked alginate beads (Alg) were prepared using the quasi-cryogelation method. Their swelling profile was investigated since alginate forms hydrogel in the presence of divalent cations. Swelling experiments were performed in two solutions, pure water and 0,9% (w/v) isotonic. Swelling ratios were found as 29% in purified water and 24% in an isotonic solution. Secondly, Alginate beads were modified by the quasi-cryogelation method. In this way, it was aimed to improve the swelling degree with the increasing porosity of beads. The swelling degree of Quasi-Alg beads was found as 295% in pure water and 260% in an isotonic solution. This study exhibits a method to increase the swelling ratio of hydrogels. Since the swelling ratio is essential for drug release to effectively release the drug or for wound dressing films to supply enough moisture to wound, Quasi-Alg beads may comprise a basis for such applications.