Investigation of some amine aromatic amines by QSAR method

In this thesis, it is aimed to investigate the effects of aromatic amines on human health and environment. In this context, raw materials commonly used in textile dyes are 2,6-dichloro-4-nitroaniline, 2.6-dibromo -4-nitro aniline, N-Cyanoethylaacetoxyethylillanil, 6-Methoxybenzothiazole-2-ylamine, 2-bromo-4,6-dinitroaniline, 4'- Aminoacetanilide, p-Acetanicide, 3'-amino-, 3-Pyridinecarbonitrile, 1,2-dihydro-6-hydroxy-1,4-dimethyl-2-oxo, 2-cyano-4-nitroaniline, N, N-Dihydroxyethyl- 3-amino-4-anisidine, N-Benzyl, N-Methylaniline, N-Cyano Ethyl N-Benzyl Aniline, 1,3,3-Trimethyl-2-Methyleneeindoline and dyestuffs produced from these raw materials (Disperse Brown 27-1, Disperse Brown 19, Disperse Orange 30, Red BS P / C, Dispers Blue 291, Dispers Yellow 27, Disperse Blue 823, Disperse Yellow 241, Disperse Blue 79, Basic Red 46, Orange 73-1, Basic Yellow 28) were examined toxicological and ecotoxicological properties by QSAR method. As a result of the studies, it has been found that the raw materials and products are generally moderate irritants. While the related raw materials generally have eye irritant properties, the products have not been shown to be irritating properties. It can be said that 25 aromatic amines have skin sensitizing properties. The raw materials of 2,6-dibromo-4-nitro aniline, 6-methoxybenzothiazole-2-ylamine, 2-bromo-4,6-dinotroaniline and Dispers Brown 27-1, Dispers Brown 19 and Dispers Blue 291 of azo dyes have been found to be mutagenic. In this thesis, in order to examine the ecotoxicological properties of aromatic amines, 2-bromo-4,6-dinitroaniline aromatic amines, which are considered as raw materials, were found to be the most toxic in Daphnia. With a value of 0.0675 mg / L LC50 of Dispers Blue 291 dye, all structures were found to show the highest toxicity in fish among aromatic amines. When aromatic amines were examined in terms of biological degradation, it was found that it does not show degradation feature in nature. While biodegradation characteristics of azo dyes have not been observed, bioaccumulation has been observed.