Experimental and theoretical study of some heterocyclic compounds

11 ABSTRACT Ph. D. Thesis EXPERIMENTAL AND THEORETICAL STUDY OF SOME HETEROCYCLIC COMPOUNDS Dilek Elmalı Anadolu University Graduate School of Sciences Chemistry Department Supervisor: Doç.Dr.Nevin Kanışkan 2004, 88 pages In this study, according to S tetter reaction in the presence of thiazolium salt catalyst 1,4-Dicabonyl derivatives, which didn't take part in literature, synthesized. According to Paal-Knorr reaction, 2,5-Disubstituted furan, pyrrole and thiophene compounds, which didn't take part in literature, were synthesized from the 1,4- dicarbonyl compounds and characterized by using spectroscopic methods. The acidity constants of 2,5-Disubstituted pyrrole, furan and thiophene derivatives were determined and by using semi-empirical quantum chemical calculation AMI method the results were searched. Keywords: Stetter Reaction, Paal-Knorr Reaction, Thiazolium Salt, Acidity Constant, Disubstituted Pyrrole