Synthesis and investigation of some new Schiff bases derived from 1,3-thiazole ring as potential biological active

Recently, the compounds which contain the heterocyclic ring, have become very important in many branches of science such as biochemistry, pesticide chemistry, pharmaceutical and medicinal chemistry. In the result of literature studies, it is known that the schiff bases show a wide range of pharmacological properties including antibacterial, anticancer, antifungal, analgesic, antiinflammatory, antitubercular and antiviral activities. In this study the target compounds, N-[4-(2-{[4-(substituted)benzilyden]amino}-1,3-thiazole-4-yl)pheyl]-3-nitrobenzamide [3a-j], were obtained by a series of reaction starting from N-(4-acetylphenyl)-3-nitrobenzamide [1]. N-(4-acetylphenyl)-3-nitrobenzamide [I] which were reacted with 4-aminoacetophenone and 3-nitrobenzoil chloride, was treated with thiourea and I2 in order to obtain new N-[4-(2-amino-1,3-thiazole-4-yl)phenyl]-3-nitrobenzamide [II]. All reactions was monitored by Thin Layer Chomatography (TLC). The structures of all synthesized compounds were proven by UV, IR, 1H-NMR and elemental analysis.