Development of a PVC membrane potentiometric sensor for the determination of benzydamine hydrochloride

Benzydamine hydrochloride is a drug active ingredient of the non-steroidal anti-inflammatory drug (NSAID) class with anesthetic and analgesic properties. It acts locally. It is used in acute (primary) inflammations due to soft tissue injury, as an anti-inflammatory, anti-edema and analgesic by affecting the local mechanisms of inflammation, and in the treatment of symptoms caused by inflammation in the mouth and throat (Turnbull, 1995). Benzydamine is a powerful psychoactive hallucinogen in case of overdose. In some people, benzydamine may be observed side effects such as stinging in the mouth, drowsiness, sudden shortness of breath, rash on the skin, swelling of the face and/or tongue, hypersensitivity reactions, allergic reactions, temporary decreased sensation and burning sensation in the mouth, nausea, vomiting, retching, skin reactions due to irritation, salivation, temporary swelling of the salivary gland, temporary contraction of the vocal cords, temporary contraction of the respiratory tract, itching accompanied by rash, urticaria (rash), sensitivity to light, and rash in the mouth Therefore, the determination of benzydamine hydrochloride is important. In this study, a benzydamine selective PVC membrane potentiometric sensor with a wide linear operating range and short response time was developed for the determination of benzydamine hydrochloride. The optimum membrane composition was determined as 1% KTpClPB, 67% NPOE, 32% PVC. For this sensor, linear range, slope, detection limit and response time were determined as 1.0x10-2 mol L-1 -1.0x10-8 mol L-1, 56.1 mV/decade, 5.0x10-9 mol L-1 and 10 seconds. The pH working range was determined as pH 3.18-7.58. The developed sensor has been successfully applied in pharmaceutical preparations.