Investigation of the rs7041 variable of VDBP gene relation withpancreatic involvement in patients with COVID-19

Objective: The new type of chorus virus disease is a disease that holds lungs and causes infection along the entire respiratory tract. It may not only infect the airway, but also cause damage to other tissue, organs, and systems in the body. One of the organs the virus targets is pancreas. Some corona virus patients lying in the clinic were found to have high levels of pancreatic enzyme. This study aims to examine whether the presence of mutation exists in the Vitamin D-connector protein (VDBP) gene rs7041 variant of the pancreatitis table for patients diagnosed with Covid-19. Method: 113 patients with normal pancreatic enzyme levels diagnosed with Covid-19 and 120 patients with both Covid-19 diagnosis and high pancreatic enzyme levels were included in the study. The rs7041 genotyping of the 11th single nucleotide variation in the VDBP gene was determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. Results: In the patient group with Covid-19 diagnosis and high pancreatic enzyme levels, the VDBP gene rs7041 variance GG genotype ratio was determined higher than the normal Covid-19 patients. As a result of comparisons between the two groups, the difference between the genotype ratios in the relationship was determined to be statistically significant (p=0,004). Conclusion: Covid-19 patients were determined that the rs7041 halves in the VDBP gene could be prone to pancreatitis formation. Different populations and work with more patient groups are needed to verify the results of the study.