Effects of lycopene against cisplatin induced nephrotoxicity on experimental diabetic rats

Today, diabetes mellitus and cancer are important diseases affecting people all over the world. Renal injury in diabetes mellitus and nephrotoxicity due to the treatment of cancer by cisplatin are significant adverse effects. In this study, was investigated to evaluate the protective effect of lycopene against nephrotoxicity in streptozotocin-induced diabetic rats. Rats were divided into five groups; while the first group was selected as control, the other groups were allocated as experimental models of diabetes by the administration of streptozotocin, Group 2 consisted of diabetes only, Group 3 diabetes plus cisplatin, Group 4 diabetes plus lycopene, and Group 5 included diabetes, cisplatin and lycopene, simultaneously. Following the applications, rats were decapitated and their blood and kidney tissues were removed, plasma urea and kreatinin levels were measured by autoanalyzer. The kidney tissue MDA, reduced GSH levels and CAT activities were determined by spectrophotometry. It was determined that the application of diabetes and cisplatin increased plasma urea/ creatinin and MDA levels, whereas it decreased catalase and GSH levels in kidney tissue. This study showed that applications of lycopene may ameliorate induced nephrotoxicity findings partially; and kidney damage induced by both diabetes and cisplatin, moderately.Key Words: Diabetes, Cisplatin, Nephrotoxicity, Lycopene, Rat