Effects of Octreotide in experimental proliferative vitreoretinopathy

Proliferative vitreoretinopathy (PVR) is the most important reason of failure after retinal detachment surgery. Although real teratment is by means of surgery, negative consequences orientate researchers to search adjuvant pharmacologic agents. In this study, it is aimed to invastigate the effect of octreotide on growth factors which have important roles on the pathogenesis of PVR.In this study, number of 21 guine pigs were randomly assigned to form three groups each including seven animals. Group 1 was defined as the control group and 0.2 ml saline solution was applied intravitreally in a location of 1.5 mm behind the limbus. Group 2 was defined as the sham group and 0.07 IU dispase in 0.1 ml and 0.1 ml saline solution were applied via the same route and 0.07 IU dispase in 0.1 ml and 1 mgr octreotide in 0.1 ml were applied intravitreally in Group 3 which was defined as the treatment group. Octreotide was applied twice during the experimental priod. At the end of 10 weeks, eyes have been dissected saggitaly through corneal apex to the optic nevre. After histopathologic preperation, formation of epiretinal membrane, corruption on internal limiting membrane, existence of retinal fold and caryopycnosis in ganglion cells were examined in every half of the eyes. The rest of the eyes were used to invastigate the levels of retinal TGF ß, IGF 1 and PDGF by ELISA.In the treatment group, histopathologic examination revealed significant decrease in epiretinal membrane formation and internal limiting membrane corruption (p<0.05) and biochemical examination observed that significant decrease in the PDGF level (p<0.05). However no change was observed in the levels of IGF 1 and TGF ß in the same group.As the result, it has been observed that octreotide might partially inhibit PVR formation. Due to its lesser side effects, it might be a more reliable and effective drug in PVR when the side effects of the previous ones are taken into account.Key Words: PVR, octreotide, growth factors