Determination of oxidative stress levels and some antioxidant activities in acute and chronic renal failure patients

In this study, antioxidant activities and oxidative stress levels were determined from serum samples taken from patients diagnosed with acute and chronic renal failure at Department of Nephrology Training and Research Hospital Van Yüzüncü Yıl University Medical Faculty. During this study, activity of three antioxidant examined, they were superoxide dismutase (SOD), reducted glutathione (GSH), and catalase (CAT). And malondialdehyde (MDA) level it is the end product of lipid peroxidation, which is a free radical source. The blood samples were taken from 92 individuals, in which 31 patients were conducted with acute renal failure, 30 patients diagnosed to have chronic renal failure, and 31 individuals were used as control group, that they did not diagnosed with renal problems. The SOD activity of patient groups is significantly lower than that of healthy control group in acute and chronic renal failure (p<0.05). Also there are significant differences in the mean of serum GSH and CAT levels in patients group compared to that of control group. In the case of patients serum MDA level is found to be a significant difference when it is compared to those of control group, while the difference of SOD and MDA average for patient and control groups were found to be relevant (p<0.05). This study shows that the oxidative stress have strong influence on the cellular damage, and tissue in acute and chronic renal failure patients. Keywords: Acute renal failure, Chronic renal failure, CAT, GSH, MDA, SOD.