Determination of some antioxidant activities (Superoxide dismutase, catalase, and reducing glutathione) and oxidative stress level (Malondialdehyde acid) in cirrhotic liver patients

Cirrhosis is a condition in which the liver does not function properly due to long-term damage. This damage is characterized by the replacement of normal liver tissue by scar tissue. Cirrhosis is most commonly caused by alcohol, hepatitis B, and hepatitis C as the most common etiological factors. In this study, blood serum samples were collected from patients with liver cirrhosis from the Gastroenterology Clinic of Batman Regional Hospital. The aim of this study was to determine the levels of lipid peroxidation (MDA) and antioxidants such as reduced glutathione (GSH), catalase (CAT) and superoxide dismutase (SOD) in the blood serum of liver cirrhosis patients. SOD, CAT and GSH activities were significantly decreased in the patient groups compared to the healthy control group (p<0.05). MDA levels were significantly higher in the patient group compared to the healthy control group (p <0.05). In conclusion, this study, oxidative stress may play an important role in the development of liver cirrhosis. Keywords: Liver Cirrhosis, SOD, GSH, CAT, MDA