The relationship between coronary collateral development and level of urotensin-ii in patients with or without diabetes mellitus

Introduction and Aim:Coronary collateral circulation consists of vascular channels which are activated to maintain perfusion in major epicardial coronary arteries in the development of severe stenosis or occlusion. Development of coronary collaterals in diabetic patients has been proven to be poor. U-II is known to be the most powerful vasoconstrictor agent. Plasma levels are known to increase in diabetic patients and plays an important role in diabetic complications. In this study, it was aimed to examine the relationship between U-II and the development of coronary collaterals.Methods:31 diabetic and 30 nondiabetic patients who have had 95% or more coronary artery stenosis or occlusion were included in the study. Collateral classification was made according to Rentrop classification. Poor Rentrop 0-1 collateral development were regarded as poor development whereas Rentrop 2-3 collateral development were regarded as good development. Serum levels of U-II were compared according to the degree of collateral developmentFindings:The demographic characteristics were not different between the two groups (p> 0.05). Development of coronary collaterals in diabetic patients was worse than those without diabetes, but not statistically significant. According to non urotensin-II levels in diabetic patients were higher (388,1 ± 314,2; 229,8 ± 216,9, p = 0.026). In nondiabetic group, urotensin-II levels were higher in patients with poor coronarycollateral development than in patients with good coronary collateral development, but it was not statistically significant (370,6 ± 298; 178,6 ± 158,3, p = 0, 2). In the diabetic group, urotensin-II levels were high in patients with poor coronary collateral development and urotensin-II levels were low in patients with good coronary collateral development and this was statistically significant (582,7 ± 316,4; 180,4 ± 121,6 P<0,0001).Results:We demonstrated that there was a significant association between urotensin-II levels and the development of coronary collateral circulation in patients with diabetes. We also determined that urotensin-II levels were low in diabetic patients with good collateral development while those with poor collateral development have a high level of urotensin-II.