Oxidative stress parameters and echocardiographic indexes in dialysis patients

Aim: Enhanced oxidative stres (OS) is present in all stages of chronic renal disease. It is suggested that hemodialysis (HD) patients are under higer risk than continous ambulatory peritoneal dialysis (CAPD) patients. In this study, the affects of OS on echocardiographic indexes in HD and CAPD patients were evaluated.Materials and Methods: 39 CAPD, 32 HD patients and 30 healthy volunters having similar demographics were included into this cross-sectional study. Who had Diabetes Mellitus and chronic inflammatory diseases were excluded. Biochemical, hematological parameters and malonyldialdehyte (MDA), glutathion peroxydase (GSH-Px), and superoxyde dismutase (SOD) were studied from sampels taken after overnight period and before mid-week dialysis session. EF, IVSd, LVPWd, and LAd were measured by M-Mode echocardiography.Results: There was no difference between patients and controls in age, gender, bodyBMI, and blood pressure. While no difference was found in MDA and GSH-Px between groups SOD was significantly lower than controls in patients (p<0.001). Age, gender, blood pressure, BMI, hemoglobin, C-RP, ferritin, calcium, iPTH, and MDA, and GSH-Px as oxidative stres parameters were similar among HD and CAPD patients. SOD levels were significantly lower in HD patients (p=0.039). Serum levels of P, albumin, and Ca-P product were higher, and serum levels of fibrinogen, total cholesterol, and LDL-Cholesterol were lower in HD patients than CAPD group. A negative corellation between MDA and EF (r=-0.380, p<0.001), and negative correlations were found between SOD and systolic blood pressure, diastolic blood pressure, phosphorus, iPTH, C-RP, fibrinogen, total cholesterol levels. Positive correlations were found between SOD and Hb, and albumin levels. MDA interacts with male gender, and EF independently. There was no correlation between antioxidants and cardiac parameters.Conculision: SOD levels as oxidative parameters may cause enhanced OS by decreasing significantly lower levels in end stage renal disease patients especially in whom undergoing HD treatment. MDA levels were correlated with age, male gender, and EF, while SOD levels had negative correlations with BP, P, iPTH, C-RP, and fibrinogen, and psitive correlations with Hb, and albumin levels.