The effect of gold nanoparticles synthesized by green synthesis method in an In Vitro Alzheimer's disease model

Alzheimer's disease (AD), which leads to performance changes in intuitive, mood and behavior, as spatial abilities are affected. The BBB barrier, the initial line of defense in the central nervous system (CNS) against the changed conditions of blood and extracellular fluid, is a highly specialized physiological barrier. By tightly regulating the flow of blood molecules into the brain, it safeguards the neurological system. Understanding the nature of the BBB leads to the development of a successful mechanism and treatment way for AD, as it is the first challenge for drug delivery into the brain. CNS is a highly intricate microenvironment within the human body and limits the development of new drugs due to the properties of the BBB. In the treatment of many diseases, the delivery of the therapeutic compound to the target site is a difficult problem. Gold nanoparticles (AuNPs) have achieved remarkable interest among many nanoparticles due to their exciting properties in optical detection and imaging, biocompatibility, facile biosynthesis methods, promising ability to penetrate BBB and minimal toxicity. Plant-generated AuNPs represent a great opportunity to be used as a vehicle in the delivery of specific therapeutics or drugs because of their antioxidant and anti-inflammatory qualities, the therapy of Alzheimer's. The primary objective of this study will be to examine the impact of gold nanoparticles produced by the green synthesis method and their effects on the in vitro amyloid-beta toxicity model.