Effects of interleukin 1 beta gene polymorphism in patients with atherosclerosis

Atherosclerosis is one of the lethal diseases worldwide. it is multifactorial disease that has several environmental and genetics involving factors. Very Serious manifestations occur in parallel to atherosclerosis, on of the most important is the cardiovascular diseases. inflammation recently thought to have a crucial role in the development of atherosclerosis, and the main mediator for the inflammatory response is IL-1 Beta. alteration within the sequence of the gene that encoding for the protein result in alteration of the production and function of the protein itself. İn our study we Determined the polymorphism of IL-1 Beta (-115) gene and its effect on atherosclerosis disease. Our study include a total of 94 people from the turkish population; 47 patients with atherosclerosis and 47 of control healthy group. IL-1 beta single nucleotide polymorphism was detected by PCR technique then the results were evaluated and analyzed. Our results showed a significant differences between patient and control groups for the homozygous mutant genotype (GG) (p=0.016) and for the heterozygous genotype (AG) (p=0.039) and for the wild type allele (A). (p=0.016) While no significant differences were found for the homozygous wild type (AA) (p=0.789) nor for the mutant allele (G) (p=0.789). After we analyzed the data, we sum up that carrying of the Heterozygote Genotype (AG) of IL-1 Beta gene is increasing risk of atherosclerosis, while carrying of the homozygous Mutant Genotype (GG) is reducing the risk. Also carrying the wild type allele A is increasing the risk. Key Words: Atherosclerosis, inflammation, Interleukin 1 beta.