Carbene precursors and carbene complexes containing electron attractive group

The design and synthesis of pharmacologically important metal-based drugs is one of the most important goals of organometallic chemists in discovering and developing modern drugs. The design of new metallodrugs often consists of the appropriate combination of metal and ligand. Therefore, other transition metals such as Ir, Rh, Os, Ru, Pd, Ag, Au have been used for the development of new potential metallopharmaceuticals. Ligands that are easy to functionalize (tunable) and form strong bonds with metals are preferred for the synthesis of these complexes. These properties are essential for the function (transport, solubility, stability) of metal-drugs, keeping the presence of the drug unaffected throughout the process and thus facilitating its excretion from the body. In this regard, N-heterocyclic carbene (NHC) ligands with biological activity and their complexes are ideal candidates. The unique properties of NHCs, such as weather and moisture stability, forming durable C-M bonds, give these ligands the ability to coordinate with almost all transition metals. On the other hand, properties such as acidity, lipophilicity, conformation, and metabolism are a common strategy for modulating the properties of a drug. For the reasons mentioned above, the main purpose of the thesis study is to include fluorine, which is the most electronegative atom, and the formyl (-CHO) group, which has the most electronegative atom, and the formyl (-CHO) group, which has the ability to be modified, into the NHC ligand and its complex, to be useful in pharmaceutical terms and to lead to the production of new generation metallodrugs. Studies carried out within the scope of this thesis: 1) 4-fluorobenzyl substituted benzimidazolium salts (2a-f), NHC-Ag(I) (3a-e), NHC-Pd(II)-pyridine (4a-e), NHC-Pd(II)-triphenylphosphine (5a-c), NHC-Pd(II)-morpholine (6a-c) complexes were synthesized and their structures were characterized by appropriate spectroscopic methods. 2) Enzyme inhibition activities of 4-fluorobenzyl substituted benzimidazolium salts (2a-f), NHC-Ag(I) (3a-e) and NHC-Pd(II)-pyridine (4a-e) complexes were examined. 3) 4-formylphenyl substituted imidazolium salts (7a-e), NHC-Pd(II)-3-chlorpyridine (8a-e) complexes were synthesized and their structures were characterized by appropriate spectroscopic methods.