In vitro fertilization (İVF) results of infertile cases determined in endometrial fluid

Aim: In this study; It was aimed to investigate whether the endometrial fluid detected in the basal ultrasonography performed on the 3rd day of the menstrual cycle and the transvaginal ultrasound performed during the controlled ovarian hyperstimulation follow-up in infertile patients who underwent IVF-ICSI / ET, whether the endometrial fluid affects the pregnancy outcomes of the patients and the etiological factors that cause endometrial fluid. Material and Methods: In this retrospective study; The data of 75 patients who applied between January 1, 2010 and March 31, 2020 to Akdeniz University Medical Faculty Hospital, Department of Gynecology and Obstetrics, Reproductive Medicine and Infertility Unit, and whose endometrial fluid was detected in their ultrasonographies, were analyzed by accessing the patients' files. Based on these records, demographic data of the patients, infertility etiologies, primary / secondary type infertility, sperm parameters in terms of male factor, ultrasonography information, whether hysteroscopy was performed, current findings, if laparoscopy was performed, current findings if performed, controlled ovarian hyperstimulation protocols (KOH) Information on pregnancy outcomes after embryo transfer has been obtained. Results: While the mean age of the pregnant women examined within the scope of the study was 32.77±5.00 years, it was seen that the mean duration of infertility was 37.99±20.62 months, basal FSH levels were 8.86±4.74 IU / l, basal LH levels were 5.61±4.97 IU / l months, and basal estradiol levels were 46.86±21.44 pg / ml of all the patients, 70,3% (n= 52) were primary infertility, 29,7% (n= 22) were secondary infertility, the most common causes of infertility were Tubaperitoneal Factors (28,4%), PCOS (16,2%) and Decreased Ovarian Reserve (13,5%). Antagonist protocol was applied in 83,8% of the patients, cycle cancellation was applied in 25,7%, the most common reasons were OHSS (36,8%), endometrial fluid (26,3%) and arrest embryo (21,1%) detected. Endometrial fluid was seen in Basal USG performed on the 3rd day of menstruation in 18,9% of the patients examined within the scope of the study, 45,9% of them had fluid during stimulation, and 35,1% had persistent endometrial fluid. While the ages of patients with endometrial fluid at basal USG were significantly higher than the other groups (p= 0.01), estradiol levels measured on the day of hCG and the number of total oocytes and embryos were found to be statistically significantly lower (p <0.05). In the group with endometrial fluid in basal USG, it was observed that the rate of pregnancy was significantly higher and the cycle cancellation was lower than the other two groups (p <0.05). In the group with persistent endometrial fluid, the incidence of polyps and hydrosalpinx was significantly higher, whereas the pregnancy rates were significantly lower (p <0.05). While lower pregnancy rates were detected in patients with tubaperitoneal factors, higher rates of pregnancy were observed in patients with unexplained infertility and PCOS (p= 0.01). Conclusion: It was concluded that low pregnancy rates were associated with the detection of persistent endometrial fluid, endometrial polyp and tubaperitoneal factors. Key Words: Infertility, tubaperitoneal factor, hydrosalpinx, endometrial polyp, endometrial fluid, in vitro fertilization.