Comparison of red blood cell transfusions effect and side effects by freshness of erythrocytes

Purpose: Blood is a living tissue, composed of plasma and cells. Blood transfusion is the same process as transplantation of cells, tissues and organs.Tranfussion of blood and blood products are life-saving treatments when used properly. With the availability of safe and effective anticoagulation methods and coming into use of plastic blood bags, blood products have been able to be stored for a long time. In addition, by the use of various preservative solutions that duration increased further.For example, retention times of erythrocyte suspensions with preservative solutions such as SAG-M, AS-1, AS-3 and AS-5 are 42 days, 35 days for CPDA-1, 21 days for CPD. It became a current issue that some undesirable effects may occur in relation to the storage period of erythrocyte suspensions. It is also known that the prolonged storage period reduces aliveness of erythrocyte. In this study, it is aimed to compare the effects and side effects in terms of erythrocyte freshness in patients who undergo transfusion of erythrocyte suspension. Materials and Methods: In this study, the efficiency and acute side effects of transfusion with regards of the age of ES in patients, who were admitted to Çukurova University Medical Faculty Internal Medicine Department between July 2016 and March 2017 for various reasons and who had undergone transfusion of erythrocyte suspension, are prospectively evaluated. Findings: 377 men (% 61.2) and 239 women (% 38.8) of 616 EST were included in the study. The average hemoglobin value was found as 7.4 g/dl and the average hematocrit value was found as 22.7 in our patients with EST. The average age of erythrocytes was 4.9 days. 478 of the transfused ES were 0-7 days old (% 77,7), 137 of the transfused ES were 8 days old and over (% 22,3). Conclusion: While each unit provides an average increase as 0,9 g/dl in hemoglobin levels after ES transfusion of 0-7 old days, each unit increased the mean hemoglobin levels by 1 g/dl after 8 days and over daily of transfusion with erythrocyte suspension and no statistically significant difference was found.There was no statistically significant difference between the two groups in terms of acute transfusion reactions.