The relationship between total leukocyte, neutrophil and lymphocyte levels with menstrual cyclus in multiple skelerosis with fingolimod therapy

Multiple Sclerosis is a chronic inflammatory autoimmune demyelinating disease of the Central Nervous System. It is thought that there are responsible interactions of environmental and genetic factors in etiology. It seems especially young adults, between 20 and 40 years of age. Generally women in the reproductive period are three times more than men. Fingolimod; is striking because it is the first oral agent to use in protective treatments. Through its similarity to the sphingosine molecule found in the cell membrane, it binds to sphingosine 1 phosphate receptors found in many tissues such as brain, cardiac, endothelial cells, kidney and liver. Lymphopenia, which is a frequent side effect of pharmacological treatment, should be followed up during the medication. It is suggested, that fingolimod is discountinuedbetween the lymphocyte counts, especially below 200 ml in blood values. In this study, it is aimed to determine the most appropriate menstrual cycle period for the monitoring of the lymphopenia, which is the advers effect of the drug, after fingolimod therapy. The study was performed in Inonu University Neurology Clinic between October 2016 and December 2016. 41 female patients with RRMS and 33 healthy female individualswere included in this study. In both groups, peripheral venous blood samples were taken from individuals at different stages of the menstrual cycle. Total leukocyte, neutrophil and lymphocyte levels were examined in these periods. As a result of this study, monitor of lymphopenia can be performed at any time during the menstrual cycle in the course of fingolimod therapy.