Investigation of the serum cytokines and plasma kisspeptin levels in hypertensive disorders of the pregnancy

Investigation of the Serum Cytokines and Plasma Kisspeptin Levels in Hypertensive Disorders of the PregnancyHypertensive disorders of the pregnancy are one of the most common causes of the maternal and neonatal morbidity and mortality. Cytokines may play an important role in physiopathologyThe aim this study is to determine the maternal serum IL-10, IL-13, TNF- ?, IFN-?, TGF-ß1 and plasma Kisspeptin levels in hypertensive disorders of the pregnancy.Between February 2008-May 2009, between ages of 18-42 years (mean age 26,1±14,1 years), 20 normal, 20 mild preeclamptic, 20 severe preeclamptic and, 20 pregnant women complicated by HELLP syndromes, total 80 pregnant women were included in to the study.It was determined that the levels of serum IL-10 (p=0,03), TNF- ? (p=0,04) and plasma Kisspeptin (p=0,01) were significantly higher in HELLP syndrome group when compared with normal pregnant group. There were no significant difference between normal and preeclamptic groups regarding the levels of serum IL-10, IL-13, TNF- ?, IFN-?, TGF- ß1 and plasma Kisspeptin. (p>0,05).This is the first study in which plasma Kisspeptin levels were determined in cases with HELLP syndrome. Kisspeptin, serum IL?10 and TNF?? levels were found significantly higher in the HELLP syndrome cases compared to the normal healthy pregnant. In conclusion, these results suggest that plasma levels of Kisspeptin, IL?10 and TNF?? might increase in cases with HELLP syndrome and this may play role in the physiopathology of this disorder.