Research of the relation between preptin, leptin and insulin resistance in gestational diabetes mellitus (GDM) diagnosis situations

Aim: Gestational diabetes is known as the disorder of glucose tolerance which occurs during first pregnancy. GDM diagnosis is crucial for the sake of the baby and the mother. In this work, it is aimed to research the applicability of Leptin and Preptin tests who are known to have an effect on insulin and glucose metabolism on GDM diagnosed pregnant patients, the insulin resistance, the parameters related to it and their correlation. Equipment and Method: Our work consists of volunteers who have filled out the application form. Among those who have volunteered by filling the participation form and became our test subjects, 41 of them form the healthy pregnant control group while 38 of them forms the GDM diagnosed group. From the blood samples taken while the test subject has an empty stomach for routine pregnancy tests, 4mL of the samples has been taken into test tubes with aprotinin and their preption and leptin parameters have been studied. Findings: In our work, for the GDM and control groups, age, BMI and the family's diabetical history factors have been found to be significant according to the p<0.05 significance level. Leptin parameters have been found to be significant according to the p<0.05 significance level while preptin parameters has been found to be insignificant p>0.05. Results: Leptin parameter has been found to be significant in GDM diagnosed pregnant patients according to the p<0.05 significance level while preptin parameters has been found to be insignificant. Keywords: Gestasyonel Diabetes Mellitus (GDM), Preptin, Leptin.