Evaluation of demographic characteristics, laboratory parameters and distribution of patients with primary glomerulonephritis in the southeast region of anatolia

Purpose: The aim of this study is to provide information about the distribution, demographic characteristics and laboratory parameters of primary glomerulonephritis (PGN) cases in our region with the results of the percutaneous kidney biopsies performed in our center and determine the epidemiology of PGN in our region. Method: In this study, 148 adult patients diagnosed PGN with percutaneous kidney biopsy between January 1 2016 - January 1 2020 at Dicle University Medical Faculty Hospital Nephrology Clinic of Internal Medicine Department were included. Patients whose biopsy sample were without immunfluorscence examination results for any reason, patients whose biopsy results which were reported as non-diagnostic, patients with history of kidney transplantation who underwent a percutaneous kidney biopsy, patients who underwent a biopsy with the suspect of malignancy were excluded. And patients with unavailable laboratory or pathological results were excluded. Results: The mean age of the patients was 38.5±12.9 years. 50% of the patients were women and 50% were men. In our study, it was found that biopsies were performed in both genders and in all age groups with the indications of nephrotic syndrome (70.3%), asymptomatic urinary abnormalities (21.6%) and acute nephritic syndrome (8.1%), respectively. The most common PGN subtypes were FSGS (41.2%) and MGN (18.9%), respectively. Following these diagnoses, the frequency order of other diagnoses was determined as IgAN (15.5%), MPGN (14.2%), RPGN (5.4%) and MDH (4.7%). The most common PGN subtype was FSGS in patients younger than 60 years old and MGN in patients older than 60 years old. It was observed that the PGN subtype with the highest average proteinuria was MGN. Conclusion: Our study is the first study on the distribution, demographic characteristics and laboratory parameters of primary glomerulonephritis in the Southeastern Anatolia Region and provides information about the PGN epidemiology of our region. The results in our study were found to be compatible with many studies in our country and around the world.