Relationship between serum arginase activity and blood lipids in children with hyperlipidemia

Objective: This study was planned to examine the activity of arginase, a hydrolytic enzyme that converts essential arginine amino acid, urea and ornithine, and to investigate its association with blood lipids in hyperlipidemic pediatric patients. Hyperlipidemia is a condition caused by elevated plasma lipids and atherogenic lipoproteins due to various causes. Materials and Methods: The study group consisted of individuals aged 0-18 years; 41 patients with hyperlipidemia and 50 healthy children. In the study, arginase enzyme activity was measured by thiosemicarbazide diacetyl monoxime urea (TDMU) method in serum samples taken from children included. The triglyceride, LDL-C, HDL-C and total cholesterol levels of the patient group and the healthy group whose diagnosis was previously determined by the pediatric clinic were measured and confirmed clinically. Results: When arginase enzyme activity was examined between patient and control groups, although there were different results, this difference was not statistically significant (p=0.777). Conclusion: In this study, it was concluded that hyperlipidemic patients had no significant association with lipid levels of arginase enzyme activity.