Researching serum and tissue level of Tenascin and Apelin in the cases histopathologically identified as endometriosis

Endometriosis is defined as having different localization apart from normal anatomic location and functional endometrial in uterus. Tenascin (TN) is a high molecular weight, extracellular, matrix glycoprotein, with a role in embryogenesis, wound healing and neoplasia, it is seen that by enhancing endothelial cell (EC) proliferation, EC migration and capillers cell formation apelin is increasing angiogenesis according to dosage. This study was planned to research whether these peptides are expressed in ectopic endometrium of phenomenon identified as endometriosis, serum level and their possible role in endometriosis physiopathology. In this study we, histopathologically, investigated the serum levels of these cases, the ectopic and eutopic endometrium tissues of 30 cases diagnosed as endometriosis and 15 cases without pelvic pathology, together with the ELISA and immunohistochemistry methods in the eutopic endometrium tissues of apelin and tenascinIn the ectopic and eutopic endometriums of the tissues with endometriosis, it was shown that apelin and tenascin was expressed together with both of the methods in the eutopic endometriums of the control group cases and compared to the proliferative phase, the expression in the secretory phase was much higher in the comparision of these internal groups. A meaningful variance has not been detected in the tissue and serum levels of these two groups.Both in the eutopic and ectopic endometrium tissues of the patients with endometriosis, apelin and tenascin expression was detected. Therefore, these findings have revealed that the etiology of endometriosis will probably be normal endometrium and might shape a new direction to the definition of endometrium reseptivness in the further advanced studies.Key words: Endometrium, endometriosis, apelin, tenascin