CD56 ve CD98 Düzeylerinin Tekrarlayan Implantasyon Başarısızlığı olan İn-vitro Fertilizasyon Hastalarındaki Önemi

Objectives Despite major advances in assisted reproductive techniques, clinical pregnancy rates remains around 31% with fresh embryo transfer and around 41% with oocyte donations. We also know that implantation process itself and the window period defined as ''implantation phase'' has significant importance in succeeding in in-vitro fertilisation (IVF) cycles. With this study we tried to define any differences of immunohistochemical staining for CD56 and CD98 within the implantation phase endometrium of both patients with recurrent implantation failure and control group which has eventually had successful IVF cycle. Study Design This is a retrospective study performed on a total of 6260 patients with IVF cycles from 2004 to 2010. Patients defined as implantation failure with failure of having positive result for b-HCG testing, following at least having 3 IVF cycles with at least total of 8 embryo transfers on the other hand control group formed with patients having success (positive b-HCG testing) on their first IVF treatment. Results Comparison of means for CD 56 staining percentages, CD 98 staining percentages, CD 98 Staining power and CD 98 staining score showed significant difference between control group and study group. (p˂.001). Conclusion We think that CD 56 and CD 98 staining for endometrium can be a part of diagnostic testing for patients who are candidates for IVF treatments. We need further studies to determine correlation between overall chances for pregnancies and these types of immunohistochemical staining for patients on IVF treatment.