Synthesis of indole-amino acid esters

Heterocyclic compounds containing nitrogen have different physiological properties. Indoles, which possess a nitrogen-containing heterocyclic structure, are compounds that can also exhibit various biological activities, including antitumor, anti- inflammatory, antibacterial, and antifibrotic effects. Some drugs, such as sumatriptan, melatonin, osimertinib, and tegaserod, are indole-based compounds that have been approved by the FDA (U.S. Food and Drug Administration). This thesis focuses on the synthesis of amino acid-indole esters obtained through the conjugation of indole, a heterocyclic compound. For this purpose, Z- or Boc-protected amino acids were activated using either the benzotriazole or DCC method, followed by interaction with 2- hydroxymethylindole to yield amino acid-indole derivatives in ester form. The structures of the newly synthesized compounds were determined using spectroscopic and analytical methods, including IR, NMR, mass spectrometry, and elemental analysis.