Research NRF2/KEAP1 road in patients with intracranial glial mass

Purpose: Gliomas makes up the majority of primary tumors that ocur in the brain parenchyma. Glioma refers to tumors that have histological features similar to glial cells. Thr primary function of Nrf2 in cells is to regulate the protective response against oxidative stress. İn this study, we aimed to evaluate whether Nrf2, Keap1, GSK 3ß, peroxynitrite and malondialdehyde can be used as biochemical markers in order to reveal the relationship between oxidative stress and glial tumors, and to contribute to the literature for the development of new pharmacotherapeutic approaches that will ultimately increase our knowledge about glial tumor etiopathogenesis. Materıal And Methods: 71 patients whose pathologies were reported as glial tumor who were operated for an intracranial tumor in Gaziantep University Faculty of Medicine, Department of Neurosurgery and 40 patients without a history of additional disease and drug use as a control group, a total of 111 patients were included in the study. Venous blood taken from the case and control groups was homogenized in the biochemistry laboratory and studied with the ELISA method; Nrf2, Keap1, GSK-3ß, malondialdehyde and peroxynitrite levels were compared. Results: İn our study, Nrf2 values were found to be statistically higher in the control group tha in the case group with high and low grade glial tumors. Keap1 values were higher in the low-grade group than in the control and high-grade groups. GSK-3ß values were not different between the groups. Peroxynitrite and MDA values, which are indicators of oxidative stress, were found to be significantly higher in the high-grade group than in the control and low-grade groups. Conclusion: The data obtained provide some evidence that Nrf2, Keap1, GSK 3ß, MDA and peroxynitrite may play a role in the etiology of glial tumors. In conclusion, we think that Nrf2 and Nrf2 modulators Keap1 and GSK-3ß, which play an important role in the regulation of oxidative stress, play a role in the pathophysiology of glial tumors together with peroxynitrite and malondialdehyde. Repeating future studies in larger and more specific tumor groups will provide a better understanding of the pathophysiology and will guide potential treatments.