The evaluation of serum alpha-1-antitrypsin levels in patients that intramuscular vitamin b12 therapy

Objective: Because of the methionines in the structure of alpha-1-antitrypsin are exposed to oxidation, alpha-1-antitrypsin lose it?s antiprotease activity. However vitamin B12 takes an active role as a cofactor during the synthesis of methionine. As a result, alpha-1-antitrypsin synthesis are claimed to increase for providing a continuous and stable levels of methionine by vitamin B12 therapy.Methods: Research was planned as an observational study. One hundred sixty nine patients were enrolled. The measurement levels of serum alpha-1-antitrypsin and vitamin B12 were compared with demographic characteristics of patients. Among the 169 patients, only 27 patients?s-who have accomplished therapeutic protocol and who have come to controls- alfa-1-antitripsin levels were controlled after treatment and compared with the before treatment levels.Results: It?s found that the higher age and Body Mass Index increase, the more alpha-1-antitrypsin levels decrease. Among the patients who use medications due to chronic diseases serum alpha-1-antitrypsin levels were found higher. Following treatment with vitamin B12, the levels of serum alpha-1-antitrypsin (before treatment 121,67±13,884, after treatment 138,04±16,922 ve P=0,001) were found increased.In conclusion, our findings show that vitamin B12 deficiency plays an important role in the ethiopathogenesis of many diseases associated with alpha-1-antitrypsin deficiency, including particularly chronic obstructive pulmonary disease.