Investigation of DNA damage binding protein 2 genetic variation in lung cancer patients in the Turkish population

Lung cancer is one of the main causes of cancer-related fatalities globally worldwide, defined by aberrant cells growing out of control in the lungs. It is primarily linked to smoking, but can also be influenced by genetic, environmental, and occupational factors. DNA repair mechanisms, specifically nucleotide excision repair (NER), are essential for preserving genomic stability and preventing cancer. The purpose of this study was to examine the relationship between polymorphisms in NER-related genes, specifically DDB2 (rs830083), among 96 NSLC patients and 96 controls within the Turkish population. Genotyping was conducted using the Fast Real-Time 7500 system (Applied Biosystems). Results showed that individuals with the homozygous GC genotype of DDB2 rs830083 had an odds ratio (OR) of 0.699 (95% CI: 0.372 - 1.312), whereas those with the CC polymorphism had an OR of 1.267 (95% CI: 0.693 – 2.318). There is no significance correlation between DDB2 polymorphism and LC, according to our research in the Turkish population, highlighting the need for further studies. These findings underscore the importance of continuing research in larger and more diverse populations to better understand genetic factors linked to lung cancer susceptibility, refine risk assessments, and guide potential treatment strategies.