Investigation of hepcidin in sera of patients with diabetic kidney disease

Diabetic kidney disease has been shown to be a major cause of kidney failure. The development of DKD may be slowed by early identification. Because the kidneys are unable to filter albumin, anemia is one of the most serious consequences of DKD, microalbuminuria is the first clinical indication of urinary albumin excretion rate (UAER) and the DKD glomerular filtration rate is less than 60 mL/min/1.73. Diabetics with kidney disease are more likely to develop anemia than those without diabetes. According to our results, people with chronic kidney disease and diabetes in their early stages are more likely to have anemia. This investigation is subject to diabetic kidney disease and iron deficiency anemia. 120 samples were separated into three groups: 60 healthy individuals. 30 people with diabetic kidney disease. and 30 subjects with type 2 diabetes. The following parameters (RBC, Hb, HCT) were measured. (TIBC, Iron, UIBC, Trf, Ferritin, glucose, urea, creatinine, albumin, total protein, and Hepcidin) Hepcidin elevation in diabetic kidney disease (DKD) was significantly different from the DM2 group and the healthy control group (p≤ 0.01). Levels of urea, creatinine, glucose, and ferritin increased throughout the investigation period. Furthermore, it was found that (iron, TIBC, UIBC, albumin, and total protein). Significantly lower (p≤0.05) when compared to the control group and DM2. Keywords: Hepcidin hormone, DKD, Chronic kidney disease, Anemia