Kanser tedavisi amaçlı nano parçacıkların sentezi ve değerlendirilmesi

Nanotechnology-based drug delivery systems have emerged as promising tools in cancer therapy, offering improved drug targeting, reduced systemic toxicity, and enhanced therapeutic efficiency. Among various nanomaterials, iron oxide nanoparticles (IONPs) are widely recognized for their biocompatibility, magnetic responsiveness, and surface modification potential. In this study, quercetin-loaded iron oxide nanoparticles (Q-IONPs) were synthesized and evaluated for their physicochemical properties and cytotoxicity against the MCF-7 breast cancer cell line. The nanoparticles were prepared using the co-precipitation method by mixing ferrous sulfate (FeSO₄) and ferric chloride (FeCl₃), followed by the addition of sodium hydroxide (NaOH) to form iron oxide nanoparticles. Quercetin was subsequently incorporated to enhance the formulation's therapeutic efficacy. Particle size analysis revealed an average hydrodynamic diameter of 394.2 ± 6.5 nm, confirming the formation of nanosized particles. Preliminary pH monitoring suggested good stability of the nanoparticles under near-physiological conditions. The cytotoxicity of Q-IONPs will be further assessed against MCF-7 cells using the MTT assay to evaluate their potential as anticancer agents. The outcome of this research is expected to provide valuable insights into the development of quercetin-based iron oxide nanoparticles as a promising nanocarrier system for targeted cancer therapy.