The relationship between inflammatory parameters and postoperative new-onset atrial fibrillation in patients who underwent isolated coronary artery bypass surgery under cardiopulmonary bypass

Objective: Different results reported regarding relationship between inflammation and POAF. Unlike the literature, this study aimed to reveal the relationship between POAF and inflammation by using many inflammation biomarkers and to investigate the power of inflammation parameters in predicting POAF. Materials and methods: One hundred ninety-one patients who underwent isolated CABG surgery with CPB were included in study. Patients were divided into two groups developing POAF (group 1, n=71) and non-developing (group 2, n=120). Changes and differences in inflammation parameters between groups preoperatively, postoperatively second and fourth-day were evaluated by risk analysis. Results: Demographic and peroperative parameters of age (p=0.038), body mass index (p=0.01), body surface area (p=0.009), pulmonary artery pressure (p=0.018), postoperative drainage (p<0.001) revealed a statistical difference between groups. POAF group revealed significant decrease in RDW on second (p<0.001) and fourth (p=0.005) postoperative days, a significant increase in NLR on fourth postoperative day (p=0.026). Multivariate logistic regression analysis revealed postoperative RDW decrease (p<0.001, OR:0.835) and PLC-R increase (p=0.034, OR:1.049) were POAF risk factors. Other inflammation parameters showed no significant difference and no risk factor was identified. Conclusion: Among 17 inflammation biomarkers included in study RDW, NLR, PLC- R were detected as predictors of POAF. Inflammation is thought to be effective in pathophysiology of POAF, but studies have published conflicting results regarding their relationship. Multicenter studies with large patient numbers can reveal this relationship more clearly and we believe that anti-inflammatory treatment in POAF prophylaxis may come to the fore in future and so prevention of POAF complications may possible.