Synthesis of chiral C2-symmetrical diamidediols and investigation of their utilities as catalyst in enantioselective addition of diethylzinc to aldehydes

In thıs study, synthesis of diamidediols were achieved. Nearly quantitatively byreacitng oxalic acids methylesters with amino alcohols directly in a single step reactions andmild conditions. Four modular and rigid diamidediols having C2-symmetry were synthesizedforming oxalyl moiety main core. The two diamidediols were synthesized first. The otherones were synthesized before, but yields were poor. The catalytic activity of C2-symmetricdiamidediols in the addiiton of diethylzinc to benzaldehyde and effects of alkyl moietybonded to stereogenıc center on enantioselectivity were investigated.The synthesized ligands were characterized by spectroscopic methods (e,g, 1H NMR,13C NMR, COSY, HETCOR, DEPT and IR ) .