Autistic features and 2D: 4D finger ratio relations children and adolescents with congenital adrenal hyperplasia

Because Kongenital adrenal hyperplasia (CAH) and Autism spectrum sis orders (ASD) is rarely seen, it is difficult to assess whether the increased incidence of ASD in girls with CAH. ASD behaviors and 2D: 4D finger ratio changes in patients with androgen overproduction have been reported. The aim of this study is determining the 2D:4D finger ratios and ASD features in girls with CAH and normal control group. The study group will consist of thirty female children and adolescents between the ages of 3 and 15 who are diagnosed with classic CAH who were followed at the Pediatric Endocrinology Department of Düzce University Medical Faculty Hospital. For the control group, 30 healthy children and adolescents equalized with CAH patients in terms of age and gender will be taken. Al patients and controls examined for psychiatric disorders. by clinicians Patients and control groups filled Autism Behavior Checklist and semi structured sociodemogrphic form that evaluated the gender, age, pregnancy and birth complications, history of mothers' cigarette and alcohol use. 2D:4D ratios were measured in both of control and CAH groups. KAH group right and left hand 2D:4D ratios were statistically lower compared to controls and also lower 2D:4D ratios had association with high ABC scores. When compared with control group, CAH group ABC scores were significantly higher. In KAH group there was a pozitive correlation between 2D:4D ratios and ABC scores. The result of low 2D:4D ratio that we have obtained from our study and the cause of ASD can be interpreted as a possible effect of testosterone hormone. In order to better define these relationships, we believe that studies should be done by increasing the number of children and adolescents of both sexes in the subtypes.