Assesment of serum prolidase level of patients with coronary artery stent restenosis

Coronary artery stent restenosis can be defined as the negative response resulting from the reduction in the veins due to the damage during coronary revascularization. Prolidase is an enzyme involved in new matrix formation in collagen metabolism and cell development. This study has been planned on the basis that the serum prolidase enzyme that has an impact on collagen formation may have an impact on in-stent restenosis. Based on what is known to date, there has been no study done on assesing the serum prolidase enzyme levels in in-stent restenosis patients. For this reason, our study objective is to identify the relationship between the in-stent restenosis and serum prolidase levels. 70 patients identified as medium or high risk on the basis of clinical or non-invasive tests and subject to an angiography in 2013-2014 at Abant Izzet Baysal University research and application hospital cardiology and emergency policlinic were included in the study. In 40 patients, in-stent restenosis was identified. In the other 30 patients, angiographically determined critical lesion was not identified. In all patients the serum prolidase levels were measured. The serum prolidase levels in the group with instent restenosis as compared to the group without was found to be meaningfully higher and to be statistically meaningful (p=0.02). In-stent restenosis was found to be meaningfully higher in smokers compared to non smokers (p=0.04). In the comparison between the increase in the stenotic stent percentage and serum prolidase levels, it was found that as the stenotic stent percentage increased the serum prolidase levels increased in a statistically meaningful way (p=0.04). The data from this study shows that serum prolidase enzyme levels are closely related to stent restenosis and are independent indicators of restenosis seriousness. Our findings lead us to think that in patients subject to coronary stent and PKG, prolidase enzyme levels may enable early and correct assessment of stent restenosis, and may contribute to the change in the treatment or determination of the timing of increasing the intensity.