Paraoxonase gene polymorphyism in coronary slow flow

ABSTRACT PARAOXONASE GENE POLYMORPHİSMS İN CORONARY SLOW FLOW Nowadays an increasing cause of morbidity and mortality of coronary artery disease continues to be (CAD) development, early diagnosis and treatment of research subjects has been. In particular, various risk scores and primary prevention efforts to attract attention. Which is suggestive of myocardial ischemia and anginal symptoms in patients with angiographically normal coronary arteries to explain the cause of chest pain is a problem frequently encountered in clinical practice. Coronary slow flow (CSF) is the angiographic findings. Coronary slow flow phenomenon (CSFP), epicardial vessels with no stenotic lesions, although there was coronary artery separately for the specified target vessel regions in coronary blood flow should reach time slower or arrive late or can not be reached is expressed as. To be more reliable diagnosis of CSF which is a quantitative method used TIMI frame count. Typical angina or angina-like chest pain suggestive of coronary artery disease, presenting with slow coronary blood flow in patients with clinical and electrocardiographic identification is very difficult. Coronary slow flow (CSFP) often emphasized the association of coronary ischemic syndromes, although the type and degree of the association of our knowledge is very limited. Paraoxonase 1 (PON 1), the structure of HDL cholesterol and oxidized LDL (OxLDL) by hydrolyzing lipid peroxides in the structure of lipoprotein oxidation is an enzyme inhibitor role. Because of this feature, seems to be protective against atherosclerosis and this effect has been shown in in vitro studies. In clinical studies of coronary artery disease (CAD) have been identified in patients with serum PON1 levels, was found to be lower compared to healthy subjects supports this view. PON1 gene therefore in recent years has been the focus of research. Several factors affecting the activity of PON1 gene have been investigated and the relationship between PON1 gene polymorphisms with CAD has been questioned. Contradictory results were obtained. Coronary slow flow phenomenon (CSFP) is still unexplained etiopathogenesis of coronary artery disease. In our study, which is considered anti-atherogenic paraoxonase 1 gene polymorphisms (M/L55, R/Q192) and aimed to investigate the effect of polymorphisms in CSFP. Keywords: Coronary slow flow, coronary artery disease, paraoxonase gene, high-density lipoprotein, low density lipoprotein