A new oxidative indicator: tiol/dysulfid homeostasis in patients with preserved ejective fractional heart failure

Background and Aims: It is suggested that myocardial dysfunction in heart failure patients may result from increased oxidative stress-related membrane changes. Thiol / disulfide homeostasis is a new oxidative stress indicator. The aim of this study was to evaluate serum thiol levels and thiol / disulfide homeostasis in patients with heart failure with preserved ejection fraction (HFpEF). Material and Method: 84 overweight or obese patient who applied to our clinic between November 2016-February 2018 and diagnosed with hypertension and left ventricule concentric hypertrophy with normal systolic function are included in the study. 42 patients who asymptomatic and have normal NT-proBNP levels (≤125) are control group. 42 patients who have cardiac failure symptoms and have high NTproBNP levels (˃125) are patient group. Results: 52.4% (n = 22) of the patient group and 54.8% (n = 23) of the control group were females. The mean age of the patient group is 31.3±10.1 years old, whereas the mean age of the control group is 32.3±8.8 years old. Native thiol, total thiol and disulfide values of the patient group are found to be significantly lower than the control group (p=0,001; p˂0,001; p=0,041 respectively). There is a statictically significant negative correlation between native thiol, total thiol values and NT-proBNP. There is a statictically significant negative correlation between native thiol, total thiol values and CA-125 values. Conclusion: As far as we know from literature, this is the first study on HFpEF and thiol/disulfide homeostasis. It is found that native, total thiol and disulfide values are low in HFpEF patients and that there is a negative correlation between native, total thiol values and NT-proBNP, CA-125 values. It can be said that oxidant / antioxidant balance is impaired in patients with HFpEF and that larger, randomized, prospective studies are needed in order to use oxidant / antioxidant balance in diagnosis and treatment of HFpEF.