Evaluation of vitamin D and e metabolism in dogs with chronic heart failure

The aim of this thesis study was to evaluate vitamin D and E metabolism in dogs with chronic heart failure. The test group material consisted of dogs which were brought to the clinic of Istanbul University-Cerrahpaşa Veterinary Faculty, Department of Internal Medicine, and which had symptomatic and detectable heart failure as a result of the examinations and healthy dogs as the control group. The sampled dogs were aged between 1-14 years. 35 of the dogs were female and 45 were male. The control group consisted of healthy dogs with characteristics similar to the breed, sex and body weight of the test group dogs. Clinical, radiographic, electrocardiographic and echocardiographic examinations were performed and those diagnosed with heart failure were classified according to ACVIM. A total of 80 specimens were collected, 10 in phase A, 30 in phase B, 30 in phase C and 10 in phase D. Echocardiographic examination, M-mode and 2-D echocardiographic imaging, measurement of left ventricular inner diameter and myocardium and laboratory measurements were also performed in the dogs. As a result of the analysis of the data obtained from the study, it was observed that calcitonin (CT) was significantly lower in dogs in the stage A and B groups compared to those in the stage D group. The cardiac troponin I level was found to be significantly higher in dogs in stage D compared to the other groups. GSH-Px level was found to be significantly higher in dogs in Stage C. Ca level was significantly higher in dogs in stages A and B than in dogs in stage D. It was observed that LA (cm), LA/Ao, LVIDd, MV E Vel, MV A Vel, MV E/A and MR Max Vel values are increased significantly as the disease stage increased. Although previous studies have reported that serum vitamins D and E play a role in dogs with chronic heart disease, our study showed that there was no significant difference in serum vitamin E and D metabolism in dogs with chronic heart disease. This result indicates that more comprehensive and more studies should be conducted to determine the relationship between vitamin D and E metabolism and heart disease.