The effects of chroni̇c peri̇odonti̇ti̇s and obesi̇ty on total anti̇oxi̇dant/oxi̇dant status and oxi̇dati̇ve stress i̇ndex

Both obesity and periodontal diseasare significant diseases that affect the quality of life, especially in developing countries. Because both disease have an inflammatory component, recent studies focus on the relationship between obesity and periodontal disease. The aim of this study is to determine the patophysiological relationship between obesity and periodontal disease by evaluating the clinical periodontal parameters and oxidative status. According to the study protocol, four groupseach ofwere consisted of twenty participants were formed. Groups were as fallows; periodontally healthy patients with normal weight (H), patients with chronic periodontitis and normal weight (CP), periodontally healthy patients with obesity (O) and patients with chronic periodontitis and obesity (OCP). Clinical periodontal parameters were recorded and serum, saliva and gingival crevicular fluid (GCF) samples were obtained. Local and sistemic levels of total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSİ) were determined biochemically. The clinial periodontal parametres were examined, and we observed that obesity don't have statistically significant affect on these parametres. TAS, TOS and OSİ valuesin serum and salivary were not statistically significant among the groups (p>0,05). GCF TAS values in S group were statistically significant higher compared to other groups(p<0,05) . GCF TOS values were increased in obese groups (O, OCP) when compared to non-obese groups (H, CP) (p<0,05). As a result we can say that obesity and chronic periodontitis does not effect oxidant/antioxidant levels in serum and saliva. One of the most important reason of detecting statistically not significant values on obese and chronic periodontitis is; different factors such as individuals daily living conditions, stress and eating habits.