The prognostic value of Suv/max'ın PET/CT and prognostic factors in Non Small Cell Cancer

Objective: We planned our work in order to investigate whether in non-small-cell lung cancer patients the maximum standard uptake values (SUVmax) correlate with survival or not and to investigate the effect of demographic, clinic and laboratory data on survival.Materials and Methods: Our study was created by the way that we retrospectively have reviewed files of patients who have applied at the Dicle University School of Medicine Chest diseases and Oncology Department between the dated of May 2006 and March 2011 who have had a definite diagnosis and using PET /BT in the staging with 101 small cell-exterior cancer patients. Of the files of the patients included in the study a statistic was made by initially recording the SUVmax value of the mass in 18 fluorodeoxyglucose pozitron emissiontomography (FDG PET) and of all other clinical, histopathological, laboratory and treatment parameters affecting the prognosis.Findings: 88 of the patients were men (%87,1) and 13 were women (%12,9). The average follow up period of the cases was 12.68 ± 11 months. In all series the average survival period was 10,62 ± 8,55 (1- 49 months). The SUVmax median value of the mass in all patient population was 12,0 (2,7 ? 35). The demographical, clinical, laboratory and radiological parameters of the patients an the median value (12,0) of SUVmax were divided into two groups and compared. The median survival 50 patients with SUVmax <12 has been 10,5 months (1,5- 43,5), the median survival of 51 patients with SUVmax ?12 has been 8 months (1?49). In terms of statistics of survival there was no significant difference (p=0.807). When we examined the effect of prognostic factors on survival with a single variable analysis it was seen that metastasis occurrence of advanced stage, high LDH level, high WBC level, that it was not surgery, that the low albumin level and low performance level did negatively affect it. In the multi variable analysis with the Cox regression method the early stage and application of surgery were independent factors for survival (p=0.002, 0.031).Result: It was considered that in the survival period of non-small-cell lung cancer patients SUVmax does not play an important role. Knowing additionally the performance condition of the patient in the tumor stage, serum LDH, WBC and albumin values may provide a better prognostic evaluation.Key words: Non-small-cell lung cancer patients, prognostic factor, SUVmax