Investigation of salicylic acid adsorption of magnetic polyethylene glycol dimetacrylate-n-vinyl caprolactam particles

The active ingredient of aspirin is acetylsalicylic acid, and it is a drug belonging to the group of non-steroidal pain relievers. It has analgesic, antipyretic and blood thinning properties. Salicylic acid, which is the raw material of aspirin, and its derivatives are found in the leaves and bark of some plants such as willow. Salicylic acid is an antiseptic and is added to some foods as a preservative. In this study, magnetic polymeric microparticles were synthesized by suspension polymerization technique. The magnetic material used in the polymerization was chosen as iron (II, III) oxide (Fe3O4) due to its superparamagnetic and biocompatible properties. This polymerization method took place in two phases. The dispersion phase is prepared by dissolving the stabilizer in pure water, and toluene is preferred because of its pore-forming feature in the organic phase. In this phase, a homogeneous mixture was obtained by mixing the initiator, crosslinker and monomer. The two phases will be mixed using a magnetic stirrer in a closed polymerization reactor and the polymerization reaction is carried out. Salicylic acid was loaded onto magnetic polymeric particles synthesized by adsorption method. The effects of concentration, temperature and time parameters on salicylic acid adsorption were investigated. Scanning Electron Microscopy (SEM),observations showed that the particles were particles. Salicylic acid adsorption on these particles was successfully performed. Developed magnetic polymeric particles are a potential candidate for drug delivery and can be used as a salicylic acid carrier for drug delivery to the site of inflammation.