Investigation of Ku70 gene polymorphisms at gastric cancer patients

The DNA repair gene Ku70, an important member of non-homologous end-joining repair system, is thought to play an important role in the repairing of DNA double strand breaks. It is known that defects in double strand break repair capacity can lead to irreversible genomic instability. However, the polymorphic variants of Ku70, have never been reported about their association with gastric cancer susceptibility. In this hospital-based case-control study, the associations of Ku70 promoter G-57C (rs2267437) and intron 3 (rs132774) polymorphisms with gastric cancer risk in Turkish population were investigated. In total, 92 patients with gastric cancer and 194 age- and gender-matched healthy controls recruited from the Dokuz Eylül University Hospital in İzmir were genotyped by real time PCR method. As for two polymorphisms, there was no difference between both groups in the distributions of their genotype frequencies. In conclusion, the Ku70promoter C-57G (rs2267437) and intron 3 (rs132774), is not associated with gastric cancer susceptibility.