Distribution of proprotein convertases in endometrium of missed abortion and voluntary first trimester evacuation cases

In this study, we have compared distribution of TNF-? (Tumour Necrosis Factor-alfa), TGF-ß2 (Tumour Growth Factor-beta 2), IGF-I (Insulin-like Growth Factor-I), POMC (Pro-opiomelanocortin), FOXO3A (Forkhead box O3A) and members of proprotein convertase family; PC4 (Proprotein Convertase 4), PC6 (Proprotein Convertase 6), PC7 (Proprotein Convertase 7) and FURIN molecules that have lots of cellular functions, in desidua and placenta samples of missed abortion and voluntary evacuation cases to investigate the effects in the etiology of missed abortion. In this study, we have compared distribution of TNF-? (Tumour Necrosis Factor-alfa), TGF-ß2 (Tumour Growth Factor-beta 2), IGF-I (Insulin-like Growth Factor-I), POMC (Pro-opiomelanocortin), FOXO3A (Forkhead box O3A) and members of proprotein convertase family; PC4 (Proprotein Convertase 4), PC6 (Proprotein Convertase 6), PC7 (Proprotein Convertase 7) and FURIN molecules that have lots of cellular functions, in desidua and placenta samples of missed abortion and voluntary evacuation cases to investigate the effects in the etiology of missed abortion. Desidual materials were collected from patients that are diagnosed missed abortion (n=10) and legal voluntary evacuation cases (n=10) under 10 gestastational week. Endometrial and placental tissue samples were blocked by tissue processing and taken serial sections from each sample. Materials were divided into two groups for examination. TNF-?, TGF-ß2, IGF-I, POMC, FOXO3A, PC4, PC6, PC7 and FURIN primary antibodies were performed by immunohistochemical staining to first group of serial sections. The number of stained cells was calculated using H-Score technique. Desidual materials were collected from patients that are diagnosed missed abortion (n=10) and legal voluntary evacuation cases (n=10) under 10 gestastational week. Endometrial and placental tissue samples were blocked by tissue processing and taken serial sections from each sample. Materials were divided into two groups for examination. TNF-?, TGF-ß2, IGF-I, POMC, FOXO3A, PC4, PC6, PC7 and FURIN primary antibodies were performed by immunohistochemical staining to first group of serial sections. The number of stained cells was calculated using H-Score technique. In this study, it is concluded that increment of TNF-?, TGF-ß, IGF-I, FOXO3A factors which play important roles in proliferation, invasion, migrasion, differentiation and survival of cells in the decidua and placenta samples, and paralleling increment of POMC, PC4, PC6 and FURİN which have roles to translate these factors into active forms from precursors via posttranslational modifications, reason of proceeding decidualization, placentation and preventing from abortion in spite of concluding the fetal life.